CBD oil information.2018-11-12T16:36:21+00:00

CBD oil information.

CBD oil information.

CBD oil information.

My supplier of the Raw paste I prepare the oil from is located in Eastern Europe where they run a farm that specializes in Hemp production for CBD oil/paste.

They produce some of the best most potent CBD its possible to make.

The Health Products Regulatory Authority (HPRA) is the independent regulator of health products in Ireland.

https://www.hpra.ie/

HPRA states: CBD oil is legal in Ireland.

Section 3: Cannabis for Medical Use A Scientific Review

EXECUTIVE SUMMARY

The Health Products Regulatory Authority (HPRA) convened an expert working group to assist with its review of the potential medical use of cannabis, as requested by the Minister for Health

 The key findings of the working group are 3.

A distinction can be drawn between cannabis products containing tetrahydrocannabinol (THC) and those, such as certain cannabidiol (CBD) oils, which contain no THC.

The latter are not subject to the Misuse of Drugs legislation, and do not contain the psychotogenic capable of causing symptoms associated with psychosis, including delusions, delirium, and hallucinations) element of cannabis.

As such, products containing only CBD are not  considered ‘controlled drugs’ and can be provided under existing legislation.

World Health Organization, a U.N. agency declares: the main ingredient in medical cannabis nonaddictive and nontoxic, according to a new report.

“In humans, CBD exhibits no effects indicative of any abuse or dependence potential,” wrote the World Health Organization, a U.N. agency that focuses on public health. Researchers spent months looking into cannabidiol, or CBD, the non-psychoactive ingredient in marijuana that’s often used for medical purposes.

It often comes in the form of oils, drops or capsules.

CBD Drug Interactions:

If the dosage of cannabidiol is low enough  it will have no noticeable effect on CYP activity but CBD may still exert other effects.

A 2013 report on a clinical trial using GW Pharmaceutical’s Sativex, a whole plant CBD rich sublingual spray found no interactions with CYP enzymes when approximately 40mg of CBD were administered.

A subsequent clinical trial, however found that 25mg of orally administered CBD significantly blocked the metabolism of an anti epileptic drug.

There is no clearly established cut off dose below which CBD does not interact with other drugs.

The general takeaway message from all of this should be that CBD is regarded as an incredibly safe and therapeutic medication, with virtually no side effects or risk for addiction/withdrawal.

A 10 ml bottle contains 260 drops.

1 drops of 1000mg full spectrum CBD oil gives approximately 3.83 mg of CBD.

3 drops of 1500mg equals 17.3mg

3 drops of 3000mg gives 34.5mg CBD

At that dose it is advisebly to take: 1 drop every 2 hours to avoid any complications if you are on prescriptions drugs.

The general takeaway message from all of this should be that CBD is regarded as an incredibly safe and therapeutic medication, with virtually no side effects or risk for addiction/withdrawal.

While much more research is needed to fully understand the interactions it may have with other medications, it’s generally accepted that, due to its wide range of use.

CBD has the potential to actually eliminate the need to take multiple medications.

Or at the very least, reduce one’s current prescription drug use.

CBD-Drug Interactions: Role of Cytochrome P450

At sufficient dosages, CBD will temporarily deactivate cytochrome P450 enzymes, thereby altering how we metabolize a wide range of compounds.

By Adrian Devitt-Lee On September 08, 2015

With cannabidiol (CBD) poised to become widely available in pharmaceutical, nutraceutical, and herbal preparations, medical scientists are taking a closer look at CBD-drug interactions.

Cannabidiol is a safe, non-intoxicating, and non-addictive cannabis compound with significant therapeutic attributes, but CBD-drug interactions may be problematic in some cases.

CBD and other plant cannabinoids can potentially interact with many pharmaceuticals by inhibiting the activity of cytochrome P450, a family of liver enzymes.

This key enzyme group metabolizes most of the drugs we consume, including more than 60 percent of marketed meds.

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At sufficient dosages, CBD will temporarily deactivate cytochrome P450 enzymes, thereby altering how we metabolize a wide range of compounds, including tetrahydrocannabinol (THC), which causes the high that cannabis is famous for.

Metabolizing CBD

The way CBD interacts with cytochrome P450 is pivotal; in essence, they deactivate each other. Preclinical research shows that CBD is metabolized by cytochrome P450 enzymes while functioning as a “competitive inhibitor” of the same liver enzymes.

By occupying the site of enzymatic activity, CBD displaces its chemical competitors and prevents cytochrome P450 from metabolizing other compounds.

The extent to which cannabidiol behaves as a competitive inhibitor of cytochrome P450 depends on how tightly CBD binds to the active site of the metabolic enzyme before and after oxidation.

This can change greatly, depending on how—and how much—CBD is administered, the unique attributes of the individual taking this medication, and whether isolated CBD or a whole plant remedy is used.

If the dosage of cannabidiol is low enough, it will have no noticeable effect on CYP activity, but CBD may still exert other effects.

There is no clearly established cut-off dose, below which CBD does not interact with other drugs.

A 2013 report on a clinical trial using GW Pharmaceutical’s Sativex, a whole plant CBD-rich sublingual spray, found no interactions with CYP enzymes when approximately 40mg of CBD were administered.

A subsequent clinical trial, however, found that 25mg of orally administered CBD significantly blocked the metabolism of an anti-epileptic drug.

How do CBD-generated changes in cytochrome P450 activity impact the metabolic breakdown of THC? Animal studies indicate that CBD pretreatment increases brain levels of THC.

That’s because CBD, functioning as a competitive inhibitor of cytochrome P450, slows down the conversion of THC into its more potent metabolite, 11-OH-THC.

Consequently, THC remains active for a longer duration, but the peak of the extended buzz is blunted somewhat under the influence of cannabidiol.

Other factors figure prominently in CBD’s ability to lessen or neutralize the THC high.

Grapefruit and Ganja

Lester Bornheim, a research pharmacologist at the University of California in San Francisco, was among the first scientists to study the metabolism of CBD.

In 1987, he was awarded a NIDA grant to investigate the effects of phytocannabinoids on cytochrome P450 enzymes.

THC and cannabinol (CBN) also inhibit CYP activity, but CBD, of all the plant cannabinoids studied, is the strongest cytochrome P450 deactivator.

“It’s a very unusual enzyme. Almost all other enzymes are designed to fit a single substrate and carry out a single chemical process resulting in a single product,” Bornheim noted.

Whereas numerous drugs are substrates for cytochrome P450, which seems to function like a generic breakdown mechanism for a wide range of exogenous and endogenous substances.

In 1999, Bornheim addressed the annual gathering of the International Cannabinoid Research Society (ICRS) and drew attention to the possibility that CBD could interfere with the metabolism of many medications.

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A year earlier, a team of Canadian scientists identified certain compounds in grapefruit that inhibit the expression of some cytochrome P450 enzymes.

Which is why physicians often warn patients not to eat grapefruit before taking their meds.

CBD, it turns out, is a more potent inhibitor of cytochrome P450 enzymes than the grapefruit compound Bergapten (the strongest of several grapefruit components that inhibit CYPs).

What does this mean in practical terms for a medical marijuana patient on a CBD-rich treatment regimen who takes a prescription blood-thinner like warfarin, for example?

CBD reduces the enzymatic degradation of warfarin, thereby increasing its duration of action and effect.

A person taking a CBD-rich product should pay close attention to changes in blood levels of warfarin, and adjust dosage accordingly as instructed by their doctor.

Cancer and Epilepsy

In cancer treatment, the precise dosing of chemotherapy is extremely important; doctors often struggle to find the maximum dose that will not be catastrophically toxic.

Many chemotherapy agents are oxidized by CYPs before their inactivation or excretion.

This means that for patients using CBD, the same dose of chemotherapy may produce higher blood concentrations.

If CBD inhibits the cytochrome-mediated metabolism of the chemotherapy and dosage adjustments aren’t made, the chemotherapy agent could accumulate within the body to highly toxic levels.

By and large, however, there have been few reported adverse cannabinoid drug interactions among the many cancer patients who use cannabis to cope with the wrenching side effects of chemotherapy.

 It is possible that whole plant cannabis, with its rich compensatory synergies, interacts differently than the isolated CBD that is administered in most research settings.

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As well, the cytoprotective effects of the cannabinoids may mitigate some of the chemotherapeutic toxicity.

Some epileptic patients have encountered issues with how CBD interacts with their anti-seizure medication.

A small clinical study at Massachusetts General Hospital involving children with refractory epilepsy found that CBD elevated the plasma levels and increased the long-term blood concentrations of clobazam, an anticonvulsant, and norclobazam, an active metabolite of this medication.

A majority of these children needed to have their dose of clobazam reduced due to side effects.

Given that both clobazam and CBD are metabolized by cytochrome P450 enzymes, a drug-drug interaction is not surprising.

Published in May 2015, the study concluded that “CBD is a safe and effective treatment of refractory epilepsy in patients receiving [clobazam].”

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But the report also emphasized the importance of monitoring blood levels for clobazam and norclobazam in patients using both CBD and clobazam.

Dr. Bonni Goldstein has observed cases in which small doses of high-CBD/low-THC cannabis oil concentrate seemed to aggravate seizure disorders rather than quell them.

How could this happen, given CBD’s renown anti-epileptic properties?

A 1992 review by Lester Bornheim and his colleagues indicated that CBD inhibits some cytochrome P450 enzymes at smaller doses than what is required for CBD to exert an anti-epileptic effect.

This means that a certain dose of CBD could alter the processing of an anti-epileptic drug taken by the patient, but this amount of CBD might not be enough to provide any anti-epileptic relief itself.

The advice some physicians offer in this situation may seem counterintuitive: Increase the dose of CBD—perhaps even add a little more THC (or THCA, the raw, unheated, non-psychoactive version of THC)—and this may be more effective for seizure control.

Enigmatic Enzymes

But why would preventing the breakdown of an anti-epileptic drug reduce its effect? There are a number of possible answers, depending on the drug in question.

The active component of the drug (the chemical that exerts an anti-epileptic effect) may be a breakdown product of the actual drug taken. So, by slowing the metabolism of the original drug, CBD would make that drug less active.

Other explanations are conceivable.

For example, if the activity of certain CYPs is slowed, the drug may be broken down by another metabolic pathway, the products of which could then interfere with the drug’s activity.

Or perhaps the inhibition of CYPs is not the predominant way that CBD interacts with certain anti-epileptic medications.

To complicate matters even further, a presentation by Dr. Kazuhito Watanabe at the 2015 International Cannabinoid Research Society meeting in Nova Scotia disclosed preliminary evidence that cannabidiol may “induce”—meaning amplify the activity of—some cytochrome P450 enzymes.

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(Induction of a protein involves increasing the transcription of its corresponding mRNA, which leads to the greater synthesis of the protein.)

This suggests that CBD can either increase or decrease the breakdown of other drugs. Again, it depends on the drug in question and the dosages used.

Any pharmaceutical, nutraceutical or green rush scheme to exploit the therapeutic potential of CBD must reckon with the fact that cannabidiol can both inactivate and enhance various cytochrome P450 enzymes in the liver—and this can potentially impact a wide range of medications.

Drug interactions are especially important to consider when using life-saving or sense-saving drugs, drugs with narrow therapeutic windows, or medications with major adverse side effects.

In particular, those who utilize high doses of CBD concentrates and isolates should keep this in mind when mixing remedies.

One of the most frequent questions I get asked about our CBD oil is why it is so expensive, and this question usually comes from people who see hemp seed oil in supermarkets at very low prices and do not understand the difference.

The short answer is because CBD oil is not exactly the same as hemp-seed oil, and also because the extraction techniques used for producing the cannabinoid-rich products are VERY different from those used for obtaining oil from hemp seeds.

Super Critical CO2 extraction

The much more expensive but non-toxic and extremely efficient method to obtain CBD oil is CO2 extraction. This requires complex equipment and expertise, but uses safe solvents and ensures a highly potent and pure extract.

The CBD oil obtained through supercritical extraction is a full spectrum cannabinoid-rich product, with numerous health benefits.

CBD  short for cannabidiol the list of medical benefits of this cannabinoid just keeps getting longer.

Unlike THC, CBD is non-psychoactive.

It’s also legal in the EU.

Time will come when mainstream media has learned that CBD had medical value.

To give you a quick summary, here are a just a handful of conditions full spectrum CBD oil has been prove successful in helping with:

Epilepsy

Cancer

Depression

Anxiety

Psychotic Disorders

Chronic Pain

Diabetes

The lesser known cannabinoids

Full spectrum CBD oil information

2. CBC

Also known as Cannabichromene, CBC is the third most common cannabinoid in the marijuana
plant overall.

In some strains, CBC may even take dominance over CBD.

CBD oil information.

Like CBD, cannabichromene is non-psychoactive.

Full spectrum CBD oil information

Here’s what you can  expect from CBC:

Anti-Inflammatory

CBC is effective at fighting inflammation on its own but 2010 research has found that it’s even more effective when combined with THC.

These findings help support the idea that cannabinoids work synergistically with each other.

Scientists have been successful in finding and isolating over 113 different compounds in the marijuana plant.

The strongest medicine is created when different components work in harmony with one another.

Anti-Tumor

When coupled with THC and other cannabinoids, CBC has also shown  promise in fighting breast cancer.

The anti-tumor effects of CBC alone are not quite as exciting as the potential of CBD, THC, and CBG but together they make for one powerful tumor-fighting combination.

Anti-Depressant

In the science world, there’s a sure-fire way to test if a rodent is depressed. You suspend it by its tail and watch to see how much it struggles to get away.

The more it struggles, the more elevated the mood of the mouse.

The test is known as the Tail Suspension Test (TST). Researchers from the University of Mississippi found that mice treated with CBC struggled significantly more than mice treated with other cannabinoids.

The amount the mice struggled depended on how much CBC they were given.

Mice given 40mg of CBC struggled less than mice that were given 80mgs.

Anti-Fungal

In a review of cannabinoid literature, author Ethan Russo reported that CBC was mildly anti-fungal.

Encourages Brain Growth

2013 study found that CBC may actually help you grow new brain cells.

Regardless of your age, cells in certain portions of your brain continue to grow through a process known as neurogenesis.

The brain portions affected are responsible for memory and learning.

You run the risk of developing diseases like Alzheimers when your brain stops developing new cells in these areas.

4.CBG

CBG is short for cannabigerol.

This cannabinoid is found early on in the growth cycle, which makes it somewhat difficult to find in large quantities.

CBG, however, is non-psychoactive.

This means that it can be cultivated via hemp.

The medical potential of CBG makes it a prime target for research these days.

Antibiotic

Cannabigerol was another one of the cannabinoids tested on the MRSA virus in 2008.

As far as antibiotic properties go, CBG was stronger than CBN and comparable to CBD. CBG is also known to be mildly anti-fungal.

Research as early as 1982 found that isolated CBG is antimicrobial and kills various types of bacteria and fungi.

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Possible Treatment for Psoriasis

This cannabinoid is one that just so happens to be good for your skin.

Not only does it help prevent the reddening of the skin but it’s been shown to have therapeutic potential for skin conditions like Psoriasis.

Pain Reliever

CBG is reportedly a more potent pain reliever than THC.

Anti-Tumor

Back in 1998, Korean researchers found that CBG was effective at slowing the growth of cancerous cells in the mouth.

More recent research published in the British Journal of Pharmacology found that CBG also had mild anti-tumor effects in prostate cancer cells.

The study focused on non-THC cannabinoids.

So while CBG did have an effect on tumor growth, it was CBD that really shined through as a potential treatment for prostate cancer.

Antidepressant & Mood-Stabilizer

As early as 1975, researchers found that CBG prevented the uptake of amino acids that help regulate mood.

The amino acid in question, GABA, was better regulated by CBG than THC or CBD.

Further studies have shown that CBG is a moderate anti-depressant, working to increase serotonin levels in your brain.

The antidepressant effects of CBG were first found in 2006 in by Richard Musty and Richard Dayo who tests conducted on lab rats.

Is CBD legal in Ireland CBD oil information

5.THCv

Short for tetrahydrocannabivarin, THCv is another cannabinoid that works in tandem with THC.

Studies cite that THCv has about 20% the psychoactive capacity as THC and recent research has shown
that THCv actually mitigates some of the negative psychoactive impacts of THC.

Anticonvulsant

Researchers out of Berkshire UK put the anti-epileptic properties of THCv to the test in rat brains.

First, they tested whether or not THCv stopped seizure-like activity in brain slices.

THCv reduced the amount of convulsive “bursts” observed when the brain segments were treated with the compound before seizures were induced.

It was then tested whether or not the cannabinoid stopped convulsions in adult rats.

They found that THCv significantly reduced seizure incidence.

Neuroprotective

You’re own experience with smoking weed shows you that you might be a little slowed down after smoking a high-THC strain.

This is where THCv comes in handy.

Smoking a strain high in THCv may help mitigate some of the short-term memory and speech impairment that goes hand-in-hand with being a little too high.

Promotes Weight Loss

There are several studies that highlight the appetite suppressant effects of CBD, more and more research is coming out linking THCV and weight loss.

paper published last year by C4 Laboratories in Arizona cited evidence that THCV decreased body fat and boosted energy metabolism in mice.

6.CBDv

CBDv is short for cannabidivarin.

Research has been done on CBDv and it looks extremely promising.

CBDv is very similar to CBD, it is a degraded version of the cannabinoid which changes the shape of the
molecule in small but significant ways.

These are a couple of the benefits CBDv can provide:

Is CBD legal in Ireland CBD oil information

Anti-Epileptic

UK’s GW Pharmaceuticals announced a patent for CBDv last year.

That patent will allow GW Pharma to create a CBDv-based anti-epileptic drug.

They’re currently undergoing phase 2 trials for the drug.

Their patent comes after a wave of research published back in 2012 and 2013.

Two separate studies isolated CBDv as a strong anticonvulsant.

The first study published in 2012 found that the cannabinoid stopped seizures in mice and rats.

second study also looked at rats and confirmed the first study’s findings.

Studies from 2014  on continue to corroborate this information.

Anti-Nausea

CBDv has also proven useful for patients with stomach or gastrointestinal issues.

2013 research out of the University of Ontario found that the compound is one hell of a nausea-fighter.

All tests prove nauseated behavior was significantly reduced in rats treated with both CBDv and THCv.

7. Delta(8)-THC  

THC is know as Delta(9)-THC.

This version is slightly different.

Delta(8) is less psychoactive than “regular” THC in adults.

Resources claim that Delta(8) has neuroprotective and anti-anxiety properties, making it an interesting companion to the more notorious psychoactive.

 Research is needed to confirm just how this particular compound acts inside the body.

Here are a couple of additional benefits you can expect from delta(8)-THC:

Appetite Stimulato

You might have thought that the familiar delta-9 THC gave you the munchies, however experiments on mice found that delta(8) increased the rodents’ appetite significantly more than delta(9).

Anti-Nausea

Back in 1995, 8 children with cancer were treated with delta(8)-THC during the course of chemotherapy.

The results of the study were actually a little odd.

While nausea and vomiting were reduced in all cases, delta(8)-THC also did not produce any psychoactive response in the children.

They were between 2 and 13-years-old.

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