Daily Dose Of CBD May Protect And Heal The Brain From Effects Of Aging.
Researchers at the University of Bonn and Hebrew University have discovered that low, regular doses of tetrahydrocannabinol (THC).
One of the main active ingredients or cannabinoids found in full spectrum CBD oil, may help to keep our brains from ‘slowing down’ as we get older.
Published today in the journal Nature Medicine, the German study revealed that while younger mice suffered a performance drop under the influence of THC.
While the psychoactive chemical gave older mice a considerable performance boost, even putting them on par with younger mice who’d abstained.
To test the chemical’s effect on brains of different ages, researchers put mice that were two months, one year, and 18 months old on a daily regimen of THC over the course of a month.
The mice were then tested on their abilities to recognize familiar objects, and to navigate a water maze in known and new configurations.
As has been similarly observed with humans, younger animals excelled at the tests when ‘sober’ but tended to struggle significantly under the influence of THC.
“Mature” and “old” mice on the other hand struggled with tasks as consistent with their brain ages at first.
But saw a huge increase in performance with THC infusions that raised their skill level up to young-mouse (drug free) standards and continued for weeks afterward.
Meanwhile, The Guardian reported, “None of the mice displayed the strange effects one might expect from doses of THC.”
CBD for social anxiety
Cannabidiol (CBD), a Cannabis sativa constituent, is a pharmacologically broad-spectrum drug that in recent years has drawn increasing interest as a treatment for a range of neuropsychiatric disorders.
The purpose of the current review is to determine CBD’s potential as a treatment for anxiety-related disorders.
By assessing evidence from preclinical, human experimental, clinical and epidemiological studies.
We found that existing preclinical evidence strongly supports CBD as a treatment for generalized anxiety disorder. Panic disorder, social anxiety disorder, obsessive–compulsive disorder, and post-traumatic stress disorder when administered acutely.
H0wever, few studies have investigated chronic CBD dosing.
Likewise, evidence from human studies supports an anxiolytic role of CBD, but is currently limited to acute dosing, also with few studies in clinical populations.
Overall, current evidence indicates CBD has considerable potential as a treatment for multiple anxiety disorders, with need for further study of chronic and therapeutic effects in relevant clinical populations.
Reduced Risk of Cancer.
Could cannabidiol help prevent tumors and other cancers before they grow?
A 2012 study showed that animals treated with CBD were significantly less likely to develop colon cancer after being induced with carcinogens in a laboratory.
Several studies had already shown that THC prevents tumors and reduces them, including one in 1996 on animal models that found that it decreased the incidence of both benign and hepatic adenoma tumors.
In 2015, scientists analyzed the medical records of over eighty-four thousand male patients in California and found that those who used cannabis, but not tobacco, had a rate of bladder cancer that was 45 percent below the norm.
Topical products can be used to treat and prevent skin cancers.
Ongoing continuing research is focused on the best ratio of CBD to THC and the most effective dose level in cancer prevention and treatment.
The role of the endocannabinoid system in the brain-gut axis
Better Cholesterol Profiles and Lowered Risk of Cardiovascular Disease
A 2013 study that measured data from 4,652 participants on the effect of CBD on metabolic systems compared non-users to current and former users.
It found that current users had higher blood levels of high-density lipoprotein (HDL-C) or “good cholesterol.”
So in the same year, an analysis of over seven hundred members of Canada’s Inuit community found that, on average, regular CBD users had increased levels of HDL-C and slightly lower levels of LDL-C (“bad cholesterol”).
Linked to diet and lifestyle, atherosclerosis is common in developed Western nations and can lead to heart disease or stroke.
It is a chronic inflammatory disorder involving the progressive depositing of atherosclerotic plaques (immune cells carrying oxidized LDL or low-density lipoproteins).
Hence a growing body of evidence suggests that endocannabinoid signaling plays a critical role in the pathology of atherogenesis.
The condition is now understood to be a physical response to injuries in the arterial walls’ lining, caused by high blood pressure, infectious microbes, or excessive presence of an amino acid called homocysteine.
Studies have demonstrated that inflammatory molecules stimulate the cycle leading to atherosclerotic lesions.E
Existing treatments are moderately effective though carry numerous side effects.
CB2 receptors triple in response to inflammation, allowing anandamide and 2-AG, the body’s natural cannabinoids, to decrease inflammatory responses.
The CB2 receptor is also stimulated by plant-based cannabinoids.